Back to the Future: Can Physical Models of Passive Membrane Permeability Help Reduce Drug Candidate Attrition and Move Us Beyond QSPR?
Author:
Publisher
Wiley
Subject
Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12074/fullpdf
Reference70 articles.
1. Why drugs fail - a study on side effects in new chemical entities;Schuster;Curr Pharm Des,2005
2. Can the pharmaceutical industry reduce attrition rates?;Kola;Nat Rev Drug Discov,2004
3. The price of innovation: new estimates of drug development costs;DiMasi;J Health Econ,2003
4. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes;Kansy;J Med Chem,1998
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