Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3-adrenoceptor activation and α1-adrenoceptor blockade

Author:

Alexandre E C1,Kiguti L R2,Calmasini F B1,Silva F H1,da Silva K P2,Ferreira R3,Ribeiro C A2,Mónica F Z1,Pupo A S2,Antunes E1

Affiliation:

1. Department of Pharmacology; University of Campinas (UNICAMP); Campinas Brazil

2. Department of Pharmacology; Institute of Biosciences, University of São Paulo State (UNESP); Botucatu São Paulo Brazil

3. Hematology and Hemotherapy Center, Faculty of Medical Sciences; University of Campinas (UNICAMP); Campinas Brazil

Publisher

Wiley

Subject

Pharmacology

Reference64 articles.

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2. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society;Abrams;NeurourolUrodyn,2002

3. Evaluation and treatment of lower urinary tract symptoms in older men;Abrams;J Urol,2013

4. Soluble guanylyl cyclase (sGC) degradation and impairment of nitric oxide-mediated responses in urethra from obese mice: reversal by the sGC activator BAY 60-2770;Alexandre;J Pharmacol Exp Ther,2014

5. The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors;Alexander;Br J Pharmacol,2013a

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