Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production-Reference-Cited by-同舟云学术

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Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production

Published:2014-11-07 Issue:1 Volume:282 Page:65-73
ISSN:1742-464X
Container-title:FEBS Journal
language:en
Short-container-title:FEBS J

Author:

Strömberg Kia¹,Eketjäll Susanna²,Georgievska Biljana¹,Tunblad Karin¹,Eliason Kristina¹,Olsson Fredrik¹,Radesäter Ann-Cathrin¹,Klintenberg Rebecka¹,Arvidsson Per I.³,von Berg Stefan⁴,Fälting Johanna³,Cowburn Richard F.¹,Dabrowski Michael¹

Affiliation:

1. Department of Neuroscience; AstraZeneca R&D; CNS/Pain iMED; Södertälje Sweden

2. AstraZeneca Translational Science Centre; Science for Life Laboratory; Solna Sweden

3. Project Management, AstraZeneca R&D; CNS/Pain iMED; Södertälje Sweden

4. Department of Medicinal Chemistry; R&I iMed; AstraZeneca R&D Mölndal; Sweden

Funder

AstraZeneca Plc

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/febs.13103/fullpdf

Reference41 articles.

1. Alzheimer's disease;Querfurth;N Engl J Med,2010

2. Alzheimer's disease: strategies for disease modification;Citron;Nat Rev Drug Discov,2010

3. Amyloid deposition as the central event in the aetiology of Alzheimer's disease;Hardy;Trends Pharmacol Sci,1991

4. Identification of a novel aspartic protease (Asp 2) as beta-secretase;Hussain;Mol Cell Neurosci,1999

5. Purification and cloning of amyloid precursor protein beta-secretase from human brain;Sinha;Nature,1999

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