Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy

Author:

Sochalska Maja1,Tuzlak Selma1,Egle Alexander2,Villunger Andreas1

Affiliation:

1. Division of Developmental Immunology; Biocenter; Medical University Innsbruck; Austria

2. Laboratory for Immunological and Molecular Cancer Research; Third Medical Department; Paracelsus Medical University; Salzburg Austria

Funder

Austrian Science Fund

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference120 articles.

1. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy;Czabotar;Nat Rev Mol Cell Biol,2013

2. Mitochondrial regulation of cell death;Tait;Cold Spring Harb Persp Biol,2013

3. Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research;Strasser;Behring Inst Mitt,1996

4. Mcl-1 deficiency results in peri-implantation embryonic lethality;Rinkenberger;Genes Dev,2000

5. Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice;Motoyama;Science (New York, NY),1995

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