The awakening of dormant neuronal precursors in the adult and aged brain

Author:

Benedetti Bruno12ORCID,Reisinger Maximilian12,Hochwartner Marie12,Gabriele Gabriele12,Jakubecova Dominika12,Benedetti Ariane12,Bonfanti Luca34ORCID,Couillard‐Despres Sebastien12ORCID

Affiliation:

1. Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI‐TReCS) Paracelsus Medical University Salzburg Austria

2. Austrian Cluster for Tissue Regeneration Vienna Austria

3. Neuroscience Institute Cavalieri Ottolenghi (NICO) Orbassano Italy

4. Department of Veterinary Sciences University of Turin Torino Italy

Abstract

AbstractBeyond the canonical neurogenic niches, there are dormant neuronal precursors in several regions of the adult mammalian brain. Dormant precursors maintain persisting post‐mitotic immaturity from birth to adulthood, followed by staggered awakening, in a process that is still largely unresolved. Strikingly, due to the slow rate of awakening, some precursors remain immature until old age, which led us to question whether their awakening and maturation are affected by aging. To this end, we studied the maturation of dormant precursors in transgenic mice (DCX‐CreERT2/flox‐EGFP) in which immature precursors were labelled permanently in vivo at different ages. We found that dormant precursors are capable of awakening at young age, becoming adult‐matured neurons (AM), as well as of awakening at old age, becoming late AM. Thus, protracted immaturity does not prevent late awakening and maturation. However, late AM diverged morphologically and functionally from AM. Moreover, AM were functionally most similar to neonatal‐matured neurons (NM). Conversely, late AM were endowed with high intrinsic excitability and high input resistance, and received a smaller amount of spontaneous synaptic input, implying their relative immaturity. Thus, late AM awakening still occurs at advanced age, but the maturation process is slow.

Publisher

Wiley

Subject

Cell Biology,Aging

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