Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as <scp>NADPH</scp> Oxidase (<scp>NOX</scp>) Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as NADPH Oxidase (NOX) Inhibitors

Published:2024-08 Issue:2 Volume:104 Page:
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Zhang Lei¹²³,Yang Xinliang⁴,Yi Rui⁵,Wu Siming¹²³,Li Qianbin¹²³,Hu Gaoyun¹²³,Chen Zhuo¹²³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences Central South University Changsha China

2. Hunan Key Laboratory of Organ Fibrosis Changsha Hunan China

3. Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases Changsha Hunan China

4. Department of Pharmacy Yueyang Central Hospital Yueyang Hunan China

5. Department of Pharmacy The First Affiliated Hospital of Hunan University of Medicine Huaihua Hunan China

Abstract

ABSTRACTNADPH oxidases (NOXs) are the sole enzyme in the human body that can directly produce reactive oxygen species. Recent studies have shown that NOXs is a very promising target for the treatment of diabetic nephropathy (DN). Here, a series of quinoline(quinolinone) derivatives have been designed based on pharmacophore strategy, synthesized and evaluated. Among them, 19d exhibits potent antiproliferative and NOXs inhibitory activities, and is worthy for further investigation.

Funder

Natural Science Foundation of Hunan Province

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14610

Reference32 articles.

1. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

2. REACTIVE OXYGEN SPECIES: Metabolism, Oxidative Stress, and Signal Transduction

3. NADPH Oxidase: An Update

4. The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology