Colchicine toxicity precipitated by interaction with sunitinib
Author:
Affiliation:
1. Department of Internal Medicine; Abington Memorial Hospital; Abington PA USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jcpt.12047/fullpdf
Reference10 articles.
1. Colchicine poisoning: the dark side of an ancient drug;Finkelstein;Clinic Toxicol,2010
2. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm174315.htm
3. Sunitinib (Sutent, SU11248) a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2;Shukla;Drug Metab Distrib,2009
4. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of P-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine;Dahan;Drug Metab Dispos,2009
5. Effect of cyclosporine on colchicine secretion by a liver canalicular transporter studied in vivo;Speeg;Hepatology,1992
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