Entecavir versus tenofovir on prognosis of hepatitis B virus‐related hepatocellular carcinoma after curative hepatectomy

Author:

Kao Wei‐Yu1234ORCID,Tan Elise Chia‐Hui5ORCID,Lee Hsin‐Lun367ORCID,Huang Yi‐Hsiang8910ORCID,Huo Teh‐Ia1112ORCID,Chang Chun‐Chao124ORCID,Chiou Jeng‐Fong367ORCID,Hou Ming‐Chih89ORCID,Wu Jaw‐Ching10ORCID,Su Chien‐Wei89101314ORCID

Affiliation:

1. Division of Gastroenterology and Hepatology, Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan

2. Division of Gastroenterology and Hepatology, Department of Internal Medicine School of Medicine, College of Medicine, Taipei Medical University Taipei Taiwan

3. Taipei Cancer Center Taipei Medical University Taipei Taiwan

4. TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan

5. Department of Health Service Administration College of Public Health, China Medical University Taichung Taiwan

6. Department of Radiation Oncology Taipei Medical University Hospital Taipei Taiwan

7. Department of Radiology School of Medicine, College of Medicine, Taipei Medical University Taipei Taiwan

8. Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan

9. Department of Internal Medicine School of Medicine, College of Medicine, National Yang Ming Chiao Tung University Taipei Taiwan

10. Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University Taipei Taiwan

11. Division of Basic Research, Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan

12. Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University Taipei Taiwan

13. Division of Holistic and Multidisciplinary Medicine, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan

14. Division of General Medicine, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan

Abstract

SummaryBackgroundThere is still controversy about whether tenofovir disoproxil fumarate (TDF) and entecavir (ETV) have different effects on the outcomes of patients with hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC).AimsThe aim of this study was to compare the prognoses between ETV and TDF treatment among patients with HBV‐related HCC after hepatectomy.MethodsAn analysis was done on data from the Taiwan Cancer Registry, which was linked to Taiwan National Health Insurance Research Database, for the years 2011–2016. We identified 7107 patients with HBV‐related HCC after curative hepatectomy, and 25.3% of them used ETV or TDF after surgery. After propensity score overlap weighting, 1797 patients treated with ETV (n = 1365) or TDF (n = 432) were included for analyses. Cox proportional hazards models were used to compare the efficacy of ETV and TDF for recurrence and overall survival (OS).ResultsAfter hepatectomy, the recurrence rate per 100 person‐years was 14.87 for the ETV group and 9.25 for the TDF group. The risk of recurrence was similar in the TDF group and the ETV group (HR [95% CI]: 0.91 [0.69–1.19; p = 0.479]), as was the risk of all‐cause mortality (HR [95% CI]: 0.67 [0.42–1.07]; p = 0.091). When considering early recurrence (<2 years) and late recurrence (≧2 years), the TDF and ETV groups showed no significant differences. Subgroup analyses and sensitivity analyses demonstrated consistent results.ConclusionBoth TDF and ETV showed similar health benefits in terms of recurrence and OS in patients with HBV‐related HCC patients after hepatectomy.

Funder

Ministry of Science and Technology, Taiwan

Taipei Veterans General Hospital

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

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