Transmitted drug resistance to NRTIs and risk of virological failure in naïve patients treated with integrase inhibitors

Author:

Borghetti A1ORCID,Ciccullo A2ORCID,Lombardi F2,Baldin G2ORCID,Belmonti S2ORCID,Prosperi M3,Incardona F4,Heger E5,Borghi V6,Sönnerborg A7,Zazzi M8,De Luca A9,Di Giambenedetto S12

Affiliation:

1. UOC Malattie Infettive Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia

2. Istituto Clinica Malattie Infettive Università Cattolica del Sacro Cuore Roma Italia

3. Department of Epidemiology University of Florida Gainesville FL USA

4. EuResist Network Rome Italy

5. Institute of Virology University of Cologne Cologne Germany

6. Clinica delle Malattie Infettive e Tropicali dell'Università di Modena e Reggio Emilia Modena Italy

7. Unit of Infectious Diseases Department of Medicine Huddinge Karolinska Institutet Karolinska University Hospital Stockholm Sweden

8. Department of Medical Biotechnology University of Siena Siena Italy

9. Infectious Diseases Unit Siena University Hospital Siena Italy

Funder

Gilead Sciences

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference10 articles.

1. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. Available athttps://aidsinfo.nih.gov/guidelines(accessed 2 March 2019).

2. EACS Guidelines Version 10.0 November 2019.

3. Impact of transmitted HIV‐1 drug resistance on the efficacy of first‐line antiretroviral therapy with two nucleos(t)ide reverse transcriptase inhibitors plus an integrase inhibitor or a protease inhibitor;Spertilli R;J AntimicrobChemother,2018

4. Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial

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