Valproate in the treatment of epilepsy in girls and women of childbearing potential

Author:

Tomson Torbjörn1,Marson Anthony23,Boon Paul4,Canevini Maria Paola5,Covanis Athanasios6,Gaily Eija7,Kälviäinen Reetta89,Trinka Eugen101112

Affiliation:

1. Department of Clinical Neuroscience; Karolinska Institutet; Stockholm Sweden

2. Department Molecular and Clinical Pharmacology; University of Liverpool; Liverpool United Kingdom

3. The Walton Centre NHS Foundation Trust; Liverpool United Kingdom

4. Reference Center for Refractory Epilepsy; Ghent University Hospital; Ghent Belgium

5. Epilepsy Center; Department of Health Sciences; San Paolo Hospital; University of Milan; Milan Italy

6. Department of Neurology; The Children Hospital “Agia Sophia”; Athens Greece

7. Department of Pediatric Neurology; Children's Hospital; University of Helsinki and Helsinki University Hospital; Helsinki Finland

8. Department of Neurology; School of Medicine; University of Eastern Finland; Kuopio Finland

9. Kuopio Epilepsy Center; Kuopio University Hospital; Kuopio Finland

10. Department of Neurology; Christian Doppler Klinik; Paracelsus Medical University Salzburg; Salzburg Austria

11. Centre for Cognitive Neuroscience; Salzburg Austria

12. Department of Public Health and Health Technology Assessment; UMIT - Health & Life Sciences University; Hall in Tirol Austria

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Reference63 articles.

1. European Medicines Agency Assessment Report. Procedure Under Article 31 of Directive 2001/83/EC Resulting from Pharmacovigilance Data 2014 http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Valproate_and_related_substances_31/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment_Committee/WC500177352.pdf

2. Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse;Nau;Toxicol Appl Pharmacol,1985

3. Valproate and the risk of congenital malformations: is formulation and dosage regime important?;Mawhinney;Seizure,2012

4. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry;Tomson;Lancet Neurol,2011

5. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study;Meador;Lancet Neurol,2013

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