Safety, pharmacokinetics and antiviral activity of ABI‐H2158 , a hepatitis B virus core inhibitor: A randomized, placebo‐controlled phase 1 study

Author:

Agarwal Kosh1ORCID,Xu Jia2,Gane Edward J.3ORCID,Nguyen Tuan T.4,Ding Yanhua2,Knox Steven J.5,Alves Katia5,Evanchik Marc5,Zomorodi Katie5,Ma Julie5,Yan Ran5,Huang Qi5,Colonno Richard5,Stamm Luisa M.5,Hassanein Tarek I.6,Kim Dong Joon7,Lim Young‐Suk8ORCID,Yuen Man‐Fung9

Affiliation:

1. Institute of Liver Studies King's College Hospital London UK

2. Phase 1 Clinical Trials Unit The First Hospital of Jilin University Jilin China

3. University of Auckland Auckland New Zealand

4. T Nguyen Research and Education, Inc. San Diego California USA

5. Assembly Biosciences, Inc. South San Francisco California USA

6. Southern California Research Center Coronado California USA

7. Hallym University Chuncheon Sacred Heart Hospital Chuncheon South Korea

8. Asan Medical Centre University of Ulsan College of Medicine Seoul South Korea

9. Department of Medicine University of Hong Kong Hong Kong Hong Kong

Publisher

Wiley

Subject

Virology,Infectious Diseases,Hepatology

Reference28 articles.

1. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

2. Organization WH.HepatitisB. In:Newsroom WHO ed. Accessed July 8 2022.https://www.who.int/news‐room/fact‐sheets/detail/hepatitis‐b2020

3. Organization WH.Global progress report on HIV viral hepatitis and sexually transmitted infections 2021: accountability for the global health sector strategies 2016–2021: actions for impact.2021.

4. Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B

5. Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa

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