Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: a feasible approach for advanced diabetes research

Author:

Heinke Sophie1,Ludwig Barbara123,Schubert Undine1,Schmid Janine1,Kiss Thomas4,Steffen Anja12,Bornstein Stefan1235,Ludwig Stefan6

Affiliation:

1. Department of Medicine III; University Hospital Carl Gustav Carus; Technische Universität Dresden; Dresden Germany

2. Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine; DZD-German Centre for Diabetes Research; Technische Universität Dresden; Dresden Germany

3. Center for Regenerative Therapies; Technische Universität Dresden; Dresden Germany

4. Department of Anesthesiology and Intensive Care Medicine; University Hospital Carl Gustav Carus; Technische Universität Dresden; Dresden Germany

5. Diabetes and Nutritional Sciences; Rayne Institute; King's College London; London UK

6. Department of Visceral-, Thoracic- and Vascular Surgery; University Hospital Carl Gustav Carus; Technische Universität Dresden; Dresden Germany

Funder

Deutsche Forschungsgemeinschaft

German Center for Diabetes Research (DZD)

Publisher

Wiley

Subject

Transplantation,Immunology

Reference35 articles.

1. Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research;Graham;Eur J Pharmacol,2015

2. The use of animal models in diabetes research;King;Br J Pharmacol,2012

3. Anomer-equilibrated streptozotocin solution for the induction of experimental diabetes in mice (Mus musculus);De la Garza-Rodea;J Am Assoc,2010

4. Streptozotocin-induced diabetes in large animals (pigs/primates): role of GLUT2 transporter and beta-cell plasticity;Dufrane;Transplantation,2006

5. Ueber die Anwendung von Novalgin in der Schweinepraxis;Schmidt;Tierarztl Umsch,1985

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