Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner

Author:

Pan Yingying1,Wang Baile2,Zheng Jujia1,Xiong Rongrong1,Fan Zhichao1,Ye Yanna1,Zhang Saisai1,Li Qinyao1,Gong Fanghua1,Wu Chaoming3,Lin Zhuofeng4,Li Xiaokun1,Pan Xuebo1ORCID

Affiliation:

1. School of Pharmaceutical Sciences; Wenzhou Medical University; Wenzhou China

2. State Key Laboratory of Pharmaceutical Biotechnology; Department of Medicine; The University of Hong Kong; Hong Kong

3. The Second Affiliated Hospital of Wenzhou Medical University; Wenzhou China

4. The First Affiliated Hospital of Jinan University; Guangzhou China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference48 articles.

1. Fibroblast growth factor 21 and its relationship with insulin sensitivity in first-degree relatives of patients with type 2 diabetes mellitus;Ors;Endokrynol Pol,2016

2. Natural history of beta-cell adaptation and failure in type 2 diabetes;Alejandro;Mol Aspects Med,2015

3. Targeting β-cell function early in the course of therapy for type 2 diabetes mellitus;Leahy;J Clin Endocrinol Metab,2010

4. Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetes;Do;Diabetologia,2016

5. The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells;Do;Diabetologia,2014

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