Achieving cancer cell death with PI3K/mTOR-targeted therapies
Author:
Affiliation:
1. Department of Biochemistry; College of Medicine, Inje University; Busan 614-735; Korea
2. Department of Molecular Biology & Biochemistry; University of California; Irvine, Irvine; California
Publisher
Wiley
Subject
History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/nyas.12028/fullpdf
Reference10 articles.
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2. mTOR Signaling in Growth Control and Disease;Laplante;Cell,2012
3. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers;Engelman;Nat. Med,2008
4. Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy;Garcia-Garcia;Clin. Cancer Res,2012
5. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor;Janes;Nat. Med,2010
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