Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity

Author:

Carls Alexandra1,Jedamzik Julia1,Witt Lukas1,Hohmann Nicolas1,Burhenne Juergen1,Mikus Gerd1

Affiliation:

1. Department of Clinical Pharmacology and Pharmacoepidemiology; University Hospital Heidelberg; Im Neuenheimer Feld 410 69120 Heidelberg Germany

Funder

DZIF (German Center for Infection Research)

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

1. P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans;Schwarz;Int J Clin Pharmacol Ther,2000

2. FDA Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers 2011 http://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm

3. The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers;Muirhead;Br J Clin Pharmacol,2002

4. Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans;Okudaira;J Clin Pharmacol,2007

5. A potentially hazardous interaction between erythromycin and midazolam;Olkkola;Clin Pharmacol Ther,1993

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