Affiliation:
1. Department of Parasitology, Faculty of Medicine University of Colombo Colombo Sri Lanka
2. Department of Pathology, Faculty of Medicine University of Colombo Colombo Sri Lanka
3. Teaching Hospital Anuradhapura Sri Lanka
Abstract
AbstractBackgroundTreatment responses to cutaneous leishmaniasis (CL) observed in Sri Lanka show variability, ranging from quick healing to delayed or failed responses to routine medication. The determinants of these differences in treatment response are not well defined. This study aimed to identify predictive features of treatment response and outcome in localized CL caused by Leishmania donovani, focusing on both clinical and histopathological findings in the patients.MethodsTissue sections (n = 103) derived from 3 mm punch biopsies of parasitologically confirmed patients were assessed. Patients were followed up weekly until complete healing of skin lesions and were reviewed at the end of 6 months and 1 year.ResultsHealing required 7–21 weekly doses of intralesional sodium stibogluconate (IL‐SSG) (mean = 12.2 ± 0.622). Twenty‐nine (28.1%) patients were identified as delayed responders. None had recurred at the end of 1 year. The demographic or clinical features (age, gender, lesion type, size, location, and lesion duration) did not significantly influence the treatment response. A heavy parasite load and acanthosis were significant predictors of a delayed response to treatment (P < 0.001). Higher parasite loads were associated with inflammation of the entire dermis (P = 0.008), more intense infiltration of macrophages (p = 0.001), and epidermal atrophy (P = 0.033). Well‐formed granulomas were inversely proportional to parasite loads.ConclusionsHistology findings proved to be better prognostic markers than clinical features for delayed responders to treatment and will aid in targeted patient management when tissue biopsies are performed in the initial diagnosis of CL.
Funder
National Institute of Allergy and Infectious Diseases
University of Colombo
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