Affiliation:
1. Steno Diabetes Center Copenhagen Herlev Denmark
2. Department of Clinical Physiology and Nuclear Medicine Rigshospitalet Glostrup Glostrup Denmark
3. Department of Medicine, Katz Family Division of Nephrology and Hypertension University of Miami Miami Florida USA
4. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Abstract
AbstractAimTo investigate the effects of ezetimibe on the urine albumin creatinine ratio (UACR) and kidney parenchyma fat content (kidney‐PF) in individuals with type 2 diabetes (T2D) and early chronic kidney disease.Materials and MethodsA randomized, double‐blind, placebo‐controlled study of ezetimibe 10 mg once daily for 16 weeks in individuals with T2D and a UACR of 30 mg/g or higher was conducted. Kidney‐PF was assessed with magnetic resonance spectroscopy. Geometric mean changes from baseline were derived from linear regressions.ResultsA total of 49 participants were randomized to ezetimibe (n = 25) or placebo (n = 24). Overall, mean ± standard deviation age was 67 ± 7 years, body mass index was 31 ± 4 kg/m2 and the proportion of men was 84%. The mean estimated glomerular filtration rate was 76 ± 22 mL/min/1.73m2 and median (first‐third quartile) UACR was 95 (41‐297) mg/g. Median kidney‐PF was 1.0% (0.3%‐2.1%). Compared with placebo, ezetimibe did not significantly reduce UACR (mean [95% confidence interval] change: −3% [−28%‐31%]) or kidney‐PF (mean change: −38% [−66%‐14%]). In participants with baseline kidney‐PF above the median, ezetimibe reduced kidney‐PF significantly (mean change: −60% [−84%‐−3%]) compared with placebo, while the reduction in UACR was not significant (mean change: −28% [−54%‐15%]).ConclusionsEzetimibe did not reduce the UACR or kidney‐PF on top of modern T2D management. However, kidney‐PF was reduced with ezetimibe in participants with high baseline kidney‐PF.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
4 articles.
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