Missorting of plasma <scp>miRNAs</scp> in aging and Alzheimer's disease-Reference-Cited by-同舟云学术

Missorting of plasma miRNAs in aging and Alzheimer's disease

Published:2023-03-27 Issue:2 Volume:165 Page:149-161
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:Journal of Neurochemistry

Author:

Čarna Maria¹^ORCID,Novotny Jan S.¹^ORCID,Dragišić Neda¹,Slavik Hanuš²³^ORCID,Sheardova Kateřina¹⁴^ORCID,Geda Yonas E.⁵^ORCID,Vyhnalek Martin¹⁶^ORCID,Laczo Jan¹⁶,Hort Jakub¹⁶^ORCID,Mao Zixu⁷^ORCID,Rissman Robert A.⁸^ORCID,Hajduch Marian²^ORCID,Dammer Eric B.⁹^ORCID,Stokin Gorazd B.¹¹⁰¹¹^ORCID

Affiliation:

1. International Clinical Research Centre St. Anne's University Hospital Brno Czech Republic

2. Institute for Molecular and Translational Medicine, Faculty of Medicine and Dentistry Palacky University Olomouc Olomouc Czech Republic

3. Department of Neurology University Hospital Olomouc Olomouc Czech Republic

4. 1st Department of Neurology, St. Anne's University Hospital and Faculty of Medicine Masaryk University Brno Czech Republic

5. Department of Neurobiology Barrow Neurological Institute Phoenix Arizona USA

6. Memory Clinic, Department of Neurology, 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czech Republic

7. Department of Pharmacology and Chemical Biology Emory University School of Medicine Atlanta Georgia USA

8. Department of Neurosciences University of California San Diego La Jolla California USA

9. Department of Biochemistry Emory University School of Medicine Atlanta Georgia USA

10. Division of Neurology University Medical Centre Ljubljana Slovenia

11. Translational Aging and Neuroscience Program Mayo Clinic Rochester Minnesota USA

Abstract

AbstractThe observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient.

image

Funder

Enoch Foundation

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15801

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