Treatment ofALK-rearranged non-small cell lung cancer: A review of the landscape and approach to emerging patterns of treatment resistance in the Australian context

Author:

Itchins M.123,Chia P.L.456,Hayes S.A.12,Howell V.M.12,Gill A.J.27,Cooper W.A.289,John T.456,Mitchell P.456,Millward M.101112,Clarke S.J.12313,Solomon B.1415,Pavlakis N.12313

Affiliation:

1. Bill Walsh Translational Research Laboratory; Kolling Institute Medical Institute of Research, Royal North Shore Hospital; St Leonards New South Wales Australia

2. Sydney Medical School; Northern Clinical School; University of Sydney; Sydney New South Wales Australia

3. Northern Cancer Institute; St Leonards New South Wales Australia

4. Medical Oncology Unit; Olivia Newton John Cancer and Wellness Centre; Austin Health; Melbourne

5. Olivia Newton-John Cancer Research Institute; Melbourne Australia

6. Department of Medicine, Dentistry and Health Sciences; The University of Melbourne; Melbourne Victoria Australia

7. Cancer Diagnosis and Pathology Group; Kolling Institute of Medical Research, Royal North Shore Hospital; St Leonards New South Wales Australia

8. Department of Tissue Pathology and Diagnostic Oncology; Royal Prince Alfred Hospital; Sydney New South Wales Australia

9. School of Medicine; Western Sydney University; Sydney New South Wales Australia

10. School of Medicine; University of Western Australia; Perth Western Australia Australia

11. Department of Medical Oncology; Sir Charles Gairdner Hospital; Nedlands Western Australia Australia

12. Linear Clinical Research; Nedlands Western Australia Australia

13. Department of Medical Oncology; Royal North Shore Hospital; St Leonards New South Wales Australia

14. Department of Medical Oncology; Peter MacCallum Cancer Centre; Melbourne Victoria Australia

15. Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville Victoria Australia

Funder

Ilse Schnell Cancer Research

NSW Ministry of Health

Publisher

Wiley

Subject

Oncology,General Medicine

Reference86 articles.

1. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer;Soda;Nature,2007

2. Estimated incidence, mortality and prevalence worldwide in 2012;International Agency for Research on Cancer. World Health Organization;GLOBOCAN 2012,2012

3. Foundation ACR Lung Cancer 2017

4. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset;Inamura;Mod Pathol,2009

5. Targeting anaplastic lymphoma kinase in lung cancer;Shaw;Clin Cancer Res,2011

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