Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial-Reference-Cited by-同舟云学术

Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial

Published:2021-09-30 Issue: Volume: Page:
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clin Transl Sci

Author:

Rymut Sharon M.¹,Sukumaran Siddharth²,Sperinde Gizette³,Bremer Meire⁴,Galanter Joshua⁵,Yoshida Kenta¹,Smith Jordan⁶,Banerjee Prajna⁷,Sverkos Viyia³,Cai Fang⁴,Steffen Verena⁸,Henderson Lindsay M.¹,Rhee Horace⁹,Belloni Paula N.⁹,Lin Joseph H.⁹,Staton Tracy L.⁴

Affiliation:

1. Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA

2. Department of Preclinical and Translational PKPD Genentech, Inc. South San Francisco California USA

3. Department of BioAnalytical Sciences Genentech, Inc. South San Francisco California USA

4. Department of Ophthalmology, Metabolism, Neurology, and Immunology Biomarker Development (OMNI‐BD) Genentech, Inc. South San Francisco California USA

5. Department of Safety Science Genentech, Inc. South San Francisco California USA

6. Department of Biostatistics F. Hoffmann‐La Roche Mississauga Ontario Canada

7. Oncology Biomarker Development Genentech, Inc. South San Francisco California USA

8. Department of Biostatistics Genentech, Inc. South San Francisco California USA

9. Early Clinical Development, Ophthalmology, Metabolism, Neurology, and Immunology (OMNI) Genentech, Inc. South San Francisco California USA

Funder

Genentech

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13163

Reference21 articles.

1. Biology of mast cell tryptase

2. Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells;Schwartz LB;J Immunol,1981

3. Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides

4. Structural Requirements and Mechanism for Heparin-dependent Activation and Tetramerization of Human βI- and βII-Tryptase

5. Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.

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