Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens

Author:

Cozzi-Lepri A1,Zangerle R2,Machala L3,Zilmer K4,Ristola M5,Pradier C6,Kirk O7,Sambatakou H8,Fätkenheuer G910,Yust I11,Schmid P12,Gottfredsson M13,Khromova I14,Jilich D15,Flisiak R16,Smidt J17,Rozentale B18,Radoi R19,Losso MH20,Lundgren JD7,Mocroft A1,

Affiliation:

1. Centre for Clinical Research, Modelling and Epidemiology; Research Department of Infection and Population Health; Institute for Global Health; University College London Medical School; Royal Free Campus London UK

2. Medical University Innsbruck; Innsbruck Austria

3. Department of Infectious and Tropical Diseases; Third Faculty of Medicine; Charles University and Na Bulovce Hospital; Prague Czech Republic

4. West-Tallinn Central Hospital; Tallinn Estonia

5. Helsinki University Hospital; Helsinki Finland

6. L'Archet 1 Hospital; University of Nice Sophia-Antipolis; Nice France

7. Rigshospitalet; University of Copenhagen; Copenhagen Denmark

8. Ippokration General Hospital; Athens Greece

9. Department of Internal Medicine 1; University Hospital of Cologne; Cologne Germany

10. German Center for Infection Research (DZIF); Partner Site Bonn-Cologne; Cologne Germany

11. Ichilov Hospital; Tel Aviv-Yafo Israel

12. Kantonsspital St. Gallen; St. Gallen Switzerland

13. Faculty of Medicine; School of Health Sciences; University of Iceland; Reykjavik, Iceland and Landspitali University Hospital; Reykjavík Iceland

14. Centre for HIV/AIDS and infectious diseases; Kaliningrad Russian Federation

15. Department of Infectious and Tropical Diseases; First Faculty of Medicine; Charles University and Na Bulovce Hospital; Prague Czech Republic

16. Department of Infectious Diseases and Hepatology; Medical University of Bialystok; Bialystok Poland

17. Ida-Viru Central Hospital; Kohtla-Jarve

18. Infectology Center of Latvia; Riga Latvia

19. Dr. Victor Babes Hospital; Bucureşti Romania

20. Hospital J.M. Ramos Mejia; Buenos Aires Argentina

Funder

Seventh Framework Programme

Bristol-Myers Squibb

Gilead Sciences

GlaxoSmithKline

Janssen Research and Development

Merck

Pfizer

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Danmarks Grundforskningsfond

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference39 articles.

1. Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies;Burger;Expert Opin Drug Metab Toxicol,2010

2. HIV integrase inhibitors in ART-experienced patients;Blanco;Curr Opin HIV AIDS,2012

3. Pharmacology of HIV integrase inhibitors;Adams;Curr Opin HIV AIDS,2012

4. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents http://www.aidsinfo.nih.gov/guidelines

5. Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort;Wittkop;J Antimicrob Chemother,2009

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