A randomized controlled phase II clinical trial comparing ONO-4053, a novel DP1 antagonist, with a leukotriene receptor antagonist pranlukast in patients with seasonal allergic rhinitis

Author:

Okubo K.1,Hashiguchi K.23,Takeda T.4,Baba K.5,Kitagoh H.6,Miho H.7,Tomomatsu H.8,Yamaguchi S.9,Odani M.10,Yamamotoya H.11ORCID

Affiliation:

1. Department of Otorhinolaryngology; Nippon Medical School; Tokyo Japan

2. Department of Otorhinolaryngology; Futaba Clinic; Tokyo Japan

3. Medical Corporation Shinanokai; Samoncho Clinic; Tokyo Japan

4. Department of Otorhinolaryngology; Takeda Clinic; Saitama Japan

5. Department of Otorhinolaryngology; Takasaka Clinic; Saitama Japan

6. Department of Otorhinolaryngology; Kitagoh Clinic; Kanagawa Japan

7. Department of Otorhinolaryngology; Miho Clinic; Kanagawa Japan

8. Department of Otorhinolaryngology; Tomomatsu Clinic; Tokyo Japan

9. Discovery Research Laboratories III; Ono Pharmaceutical Co., Ltd.; Osaka Japan

10. Data Science; Ono Pharmaceutical Co., Ltd.; Osaka Japan

11. Translational Science; Ono Pharmaceutical Co., Ltd.; Osaka Japan

Funder

Ono Pharmaceutical Co., Ltd

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference40 articles.

1. Allergic rhinitis and its impact on asthma (ARIA) 2008;Bousquet;Allergy,2008

2. The diagnosis and management of rhinitis: an updated practice parameter;Wallace;J Allergy Clin Immunol,2008

3. Japanese guideline for allergic rhinitis 2014;Okubo;Allergol Int,2014

4. Clinical practice guideline: allergic rhinitis;Seidman;Otolaryngol Head Neck Surg,2015

5. Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE;Lewis;J Immunol,1982

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