Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins
Author:
Affiliation:
1. Novartis Institutes for Biomedical Research; Horsham West Sussex UK
2. School of Life Sciences; University of Nottingham; Nottingham UK
3. Roche Innovation Center Basel; Switzerland
4. Department of Mathematics; University of Surrey; Guildford UK
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.13263/fullpdf
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4. Miniaturized receptor binding assays: complications arising from ligand depletion;Carter;J Biomol Screen,2007
5. Determination of serum protein binding affinity of inhibitors from analysis of concentration-response plots in biochemical activity assays;Copeland;J Pharm Sci,2000
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