Gentisic acid attenuates pressure overload-induced cardiac hypertrophy and fibrosis in mice through inhibition of the ERK1/2 pathway

Author:

Sun Simei123,Kee Hae Jin12ORCID,Jin Li4,Ryu Yuhee12,Choi Sin Young12,Kim Gwi Ran12,Jeong Myung Ho12

Affiliation:

1. Heart Research Center; Chonnam National University Hospital; Gwangju Korea

2. Hypertension Heart Failure Research Center; Chonnam National University Hospital; Gwangju Korea

3. Molecular Medicine; Brain Korea 21 PLUS; Chonnam National University Graduate School; Gwangju Korea

4. The Second Affiliated Hospital & Yuying Children's Hospital Wenzhou Medical University; Wenzhou China

Funder

Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea

National Research Foundation of Korea

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference45 articles.

1. Transverse aortic constriction in mice;deAlmeida;J Vis Exp,2010

2. Cardiac remodeling: concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment;Azevedo;Arq Bras Cardiol,2016

3. The influence of antihypertensive drug treatment on the prevention and regression of left ventricular hypertrophy;Zwieten;Cardiovasc Res,2000

4. MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets;Muslin;Clin Sci (Lond),2008

5. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice;Bueno;EMBO J,2000

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