Results of a randomized phase III/IV trial comparing intermittent bolus versus continuous infusion of antihaemophilic factor (recombinant) in adults with severe or moderately severe haemophilia A undergoing major orthopaedic surgery

Author:

Pabinger Ingrid1ORCID,Mamonov Vasily2,Windyga Jerzy3ORCID,Engl Werner4,Doralt Jennifer4,Tangada Srilatha5,Spotts Gerald5,Ewenstein Bruce5

Affiliation:

1. Medical University of Vienna Vienna Austria

2. National Research Center for Hematology Moscow Russia

3. Department of Disorders of Hemostasis and Internal Medicine Institute of Hematology and Transfusion Medicine Warsaw Poland

4. Baxalta Innovations GmbH, a Takeda company Vienna Austria

5. Baxalta US Inc., a Takeda company Cambridge Massachusetts USA

Publisher

Wiley

Subject

Genetics (clinical),Hematology,General Medicine

Reference24 articles.

1. ADVATE (antihemophilic factor [recombinant]) [summary of product characteristics];2013.http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_‐_Product_Information/human/000520/WC500022467.pdf. Accessed August 20 2018

2. ADVATE (antihemophilic factor [recombinant]).Westlake Village CA:Baxalta US Inc;2016.

3. Comparison of continuous and intermittent factor VIII concentrate therapy in hemophilia A

4. The use of continuous infusion of factor concentrates in the treatment of hemophilia

5. Coagulation factor concentrates by continuous infusion

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