The effects of sports‐related concussion history on female adolescent brain activity and connectivity for bilateral lower extremity knee motor control

Author:

Zuleger Taylor M.1234ORCID,Slutsky‐Ganesh Alexis B.1235ORCID,Anand Manish1236,Kim HoWon7ORCID,Warren Shayla M.123ORCID,Grooms Dustin R.789ORCID,Barber Foss Kim D.123ORCID,Riley Michael A.10,Yuan Weihong1112ORCID,Gore Russell K.1314ORCID,Myer Gregory D.1152316ORCID,Diekfuss Jed A.123ORCID

Affiliation:

1. Emory Sports Performance And Research Center (SPARC) Georgia Flowery Branch USA

2. Emory Sports Medicine Center Georgia Atlanta USA

3. Department of Orthopaedics Emory University School of Medicine Georgia Atlanta USA

4. University of Cincinnati Neuroscience Graduate Program Ohio Cincinnati USA

5. Department of Kinesiology University of North Carolina at Greensboro North Carolina Greensboro USA

6. Department of Mechanical Engineering Indian Institute of Technology Madras Chennai India

7. Ohio Musculoskeletal & Neurological Institute Ohio University Ohio Athens USA

8. Division of Athletic Training School of Applied Health Sciences and Wellness, College of Health Sciences and Professions, Ohio University Ohio Athens USA

9. Division of Physical Therapy School of Rehabilitation and Communication Sciences, College of Health Science and Professions, Ohio University, Grover Center Ohio Athens USA

10. Department of Rehabilitation, Exercise, & Nutrition Sciences University of Cincinnati Ohio Cincinnati USA

11. Pediatric Neuroimaging Research Consortium Cincinnati Children's Hospital Medical Center Ohio Cincinnati USA

12. College of Medicine, University of Cincinnati Ohio Cincinnati USA

13. Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Georgia Atlanta USA

14. Shepherd Center Georgia Atlanta USA

15. Youth Physical Development Centre Cardiff Metropolitan University Wales UK

16. The Micheli Center for Sports Injury Prevention Massachusetts Waltham USA

Abstract

AbstractSports‐related concussions (SRCs) are associated with neuromuscular control deficits in athletes following return to play. However, the connection between SRC and potentially disrupted neural regulation of lower extremity motor control has not been investigated. The purpose of this study was to investigate brain activity and connectivity during a functional magnetic resonance imaging (fMRI) lower extremity motor control task (bilateral leg press) in female adolescent athletes with a history of SRC. Nineteen female adolescent athletes with a history of SRC and nineteen uninjured (without a history of SRC) age‐ and sport‐matched control athletes participated in this study. Athletes with a history of SRC exhibited less neural activity in the left inferior parietal lobule/supramarginal gyrus (IPL) during the bilateral leg press compared to matched controls. Based upon signal change detected in the brain activity analysis, a 6 mm region of interest (seed) was defined to perform secondary connectivity analyses using psychophysiological interaction (PPI) analyses. During the motor control task, the left IPL (seed) was significantly connected to the right posterior cingulate gyrus/precuneus cortex and right IPL for athletes with a history of SRC. The left IPL was significantly connected to the left primary motor cortex (M1) and primary somatosensory cortex (S1), right inferior temporal gyrus, and right S1 for matched controls. Altered neural activity in brain regions important for sensorimotor integration and motor attention, combined with unique connectivity to regions responsible for attentional, cognitive, and proprioceptive processing, indicate compensatory neural mechanisms may underlie the lingering neuromuscular control deficits associated with SRC.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

Subject

Experimental and Cognitive Psychology,Neuropsychology and Physiological Psychology,Biological Psychiatry,Cognitive Neuroscience,Developmental Neuroscience,Endocrine and Autonomic Systems,Neurology,Experimental and Cognitive Psychology,Neuropsychology and Physiological Psychology,General Neuroscience

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