A J‐shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross‐sectional study

Author:

Liu Ying12,Wang Jingyu1,Xu Fang13,Zhang Shuang14ORCID,Cui Shanshan12,Li Yongmei1,Wang Xiaoyu12,Zheng Hui15,Li Junfeng2,Kong Yan1,Yang Juhong1,Jiang Xia2,Chang Baocheng1ORCID

Affiliation:

1. NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien‐I Memorial Hospital & Tianjin Institute of Endocrinology Tianjin Medical University Tianjin China

2. Endocrinology Department Tianjin First Central Hospital, Nankai University Tianjin China

3. Endocrinology Department, Inner Mongolia Baogang Hospital Third Affiliated Hospital of Inner Mongonia Medical University Baotou China

4. Tianjin Women's and Children's Health Center Tianjin China

5. Endocrinology Department TEDA International Cardiovascular Hospital Tianjin China

Abstract

AbstractAimTo investigate the association between circulating β‐hydroxybutyric acid (βOHB) and diabetic kidney disease (DKD) risk in patients with type 2 diabetes (T2D).Materials and MethodsA total of 1388 patients with T2D were recruited. Participants were divided into high and normal βOHB groups. Participants in the normal βOHB group were divided into four subgroups according to βOHB quartile (Q). The relationships of βOHB with DKD and DKD subtype were analysed using chi‐square and binary logistic regression. Restricted cubic splines were used to explore the non‐linear correlation between βOHB concentration and DKD risk in the total population.ResultsA higher prevalence of DKD was detected in the high compared with the normal βOHB group (43.3% vs. 33.3%, P = .041). Participants in the Q4 group (βOHB, 0.12‐0.30 mM) had the lowest prevalence of DKD (P = .001). In the binary logistic regression model, the multivariable‐adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for DKD risk were 2.30 (1.62‐3.26) for Q1, 1.80 (1.23‐2.62) for Q2 and 1.63 (1.10‐2.41) for Q3 relative to Q4 (P < .001). Restricted cubic spline analyses suggested a J‐shaped association of circulating βOHB concentration with DKD risk. DKD risk was lowest at a serum βOHB concentration of 0.183 mM (OR, 0.63; 95% CI, 0.52‐0.77).ConclusionsA J‐shaped relationship between circulating ketone level and DKD risk in patients with T2D was determined. Circulating βOHB in the range of 0.12‐0.30 mM was associated with a lower risk of DKD. Further studies are warranted to verify the causality and to elucidate the underlying mechanisms.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3