Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

Author:

TeBay Clifford1ORCID,McArthur Jeffrey R.12,Mangala Melissa13,Kerr Nicholas13,Heitmann Stewart1,Perry Matthew D.14,Windley Monique J.13,Vandenberg Jamie I.13,Hill Adam P.13ORCID

Affiliation:

1. Molecular Cardiology and Biophysics Victor Chang Cardiac Research Institute Sydney New South Wales Australia

2. Illawarra Health and Medical Research Institute University of Wollongong Wollongong New South Wales Australia

3. St. Vincent's Clinical School UNSW Sydney Sydney New South Wales Australia

4. School of Medical Sciences UNSW Sydney Sydney New South Wales Australia

Funder

New South Wales Government

Publisher

Wiley

Subject

Pharmacology

Reference64 articles.

1. The Concise Guide to PHARMACOLOGY 2021/22: Ion channels;Alexander S. P.;British Journal of Pharmacology,2021

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3. In vivo activity of the macrolide antibiotics azithromycin, roxithromycin and spiramycin against Toxoplasma gondii;Araujo F. G.;European Journal of Clinical Microbiology & Infectious Diseases,1991

4. Torsades de pointes in SARS‐CoV‐2 (COVID‐19) pneumonia: Medicine reconciliation and careful monitoring of QTc interval may help prevent cardiac complications;Aslam W.;BMJ Case Reports,2021

5. Co‐expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events;Ballouz S.;Cardiovascular Research,2020

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