Associations of polypharmacy with frailty severity and each frailty phenotype in community‐dwelling older adults: Itabashi Longitudinal Study on Aging

Author:

Daimaru Kaori1ORCID,Osuka Yosuke12ORCID,Kojima Narumi1,Mizukami Katsuyoshi3ORCID,Motokawa Keiko1,Iwasaki Masanori14ORCID,Inagaki Hiroki1ORCID,Miyamae Fumiko1,Okamura Tsuyoshi1,Hirano Hirohiko1,Awata Shuichi5,Sasai Hiroyuki1

Affiliation:

1. Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan

2. Department of Frailty Research, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology Obu Japan

3. Faculty of Health and Sport Sciences University of Tsukuba Tokyo Japan

4. Department of Preventive Dentistry, Faculty of Dental Medicine and Graduate School of Dental Medicine Hokkaido University Sapporo Japan

5. Integrated Research Initiative for Living Well with Dementia, Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan

Abstract

AimAlthough polypharmacy and frailty are concerns in older adults, there is limited understanding of their association, particularly regarding frailty severity and its phenotypes within this population. This study aimed to examine the association between polypharmacy and frailty severity or frailty phenotypes in community‐dwelling older Japanese adults.MethodsThis cross‐sectional study included 1021 older adults from the Itabashi Longitudinal Study on Aging. Men accounted for 45.4%, and the mean age (standard deviation) was 77.9 (5.1) years. Participants were classified into frail (n = 67), pre‐frail (n = 543), and robust (n = 411) groups using the revised Japanese Cardiovascular Health Study criteria. Polypharmacy was defined as using five or more self‐reported prescription drugs. Ordinal and binomial logistic regression analyses examined the association between polypharmacy and frailty severity or frailty phenotypes (weight loss, weakness, exhaustion, slowness, and low activity). These models were adjusted for age, sex, body mass index, number of comorbidities, living status, employment status, years of education, as well as drinking and smoking habits.ResultsThe prevalence of frailty in participants with and without polypharmacy was 10.1% and 5.0%, respectively. Participants with polypharmacy were more likely to have frailty (adjusted odds ratio [95% confidence interval], 1.89 [1.40–2.57]), weight loss (1.81 [1.00–3.27]), weakness (1.50 [1.08–2.09]), and slowness (2.25 [1.29–3.94]) compared with the no‐polypharmacy group.ConclusionsPolypharmacy was associated with frailty severity and three frailty phenotypes. Longitudinal studies are required to investigate whether polypharmacy can predict the development and progression of frailty. Geriatr Gerontol Int 2024; 24: 196–201.

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3