Cerebral palsy in African paediatric populations: A scoping review

Author:

Murugasen Serini12ORCID,Springer Priscilla1,Olusanya Bolajoko O.3ORCID,Gladstone Melissa45,Newton Charles67ORCID,Kakooza‐Mwesige Angelina8ORCID,Donald Kirsten A.29ORCID

Affiliation:

1. Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences Stellenbosch University Stellenbosch South Africa

2. Division of Developmental Paediatrics, Department of Paediatrics and Child Health Red Cross War Memorial Children's Hospital, University of Cape Town Cape Town South Africa

3. Centre for Healthy Start Initiative Lagos Nigeria

4. Department of Women's and Children's Health University of Liverpool Liverpool UK

5. Department of Paediatrics Kamuzu University of Health Sciences Blantyre Malawi

6. Department of Psychiatry University of Oxford Oxford UK

7. Kenya Medical Research Institute‐Wellcome Trust Collaborative Programme Kilifi Kenya

8. Department of Paediatrics and Child Health Makerere University College of Health Sciences Kampala Uganda

9. Neuroscience Institute University of Cape Town Cape Town South Africa

Abstract

AbstractAimTo review the epidemiology and outcomes of African children with cerebral palsy (CP) over a 21‐year period.MethodThe PubMed, Scopus, and Web of Science online databases were searched for original research on African children with CP aged 18 years and younger published from 2000 to 2021.ResultsA total of 1811 articles underwent review against explicit criteria; 93 articles were selected for inclusion in the scoping review. The reported prevalence of CP ranged from 0.8 to 10 per 1000 children. Almost half had perinatal risk factors, but up to 26% had no identifiable risk factor. At least one‐third of children with CP had one or more comorbidities, most commonly epilepsy, intellectual disability, and malnutrition. African children with CP demonstrated excess premature mortality approximately 25 times that of the general population, predominantly from infections. Hospital‐based and younger populations had larger proportions of children with severe impairments. African children with CP had inadequate access to care and education, yet showed functional improvements compared to controls for all evaluated interventions.InterpretationThe prevalence of CP in Africa remains uncertain. African children with CP have different risk profiles, greater premature mortality, and more severe functional impairments and comorbidities compared to the Global North. Several barriers prevent access to optimal care. Larger African studies on validated and effective interventions are needed.

Publisher

Wiley

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