Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions
Author:
Affiliation:
1. Department of Cellular and Molecular Medicine; Lerner Research Institute; Cleveland OH USA
2. Department of Molecular Medicine; Case Western Reserve University; Cleveland OH USA
Funder
National Institutes of Health
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.12712/fullpdf
Reference46 articles.
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2. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules;Heijnen;Blood,1999
3. Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction;Gambim;Crit Care,2007
4. Platelet-derived exosomes from septic shock patients induce myocardial dysfunction;Azevedo;Crit Care,2007
5. Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice;Ghosh;J Clin Invest,2008
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