Interplay between speech and gait variables in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation: A long‐term instrumental assessment-Reference-Cited by-同舟云学术

Interplay between speech and gait variables in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation: A long‐term instrumental assessment

Published:2023-04-10 Issue:7 Volume:30 Page:1963-1972
ISSN:1351-5101
Container-title:European Journal of Neurology
language:en
Short-container-title:Euro J of Neurology

Author:

Cavallieri Francesco¹²^ORCID,Gessani Annalisa³,Merlo Andrea⁴^ORCID,Campanini Isabella⁴^ORCID,Budriesi Carla³^ORCID,Fioravanti Valentina¹,Di Rauso Giulia¹³,Feletti Alberto⁵⁶,Damiano Benedetta⁴,Scaltriti Sara⁴,Guagnano Noemi⁴,Bardi Elisa³,Corni Maria Giulia³,Antonelli Francesca³,Cavalleri Francesca⁷,Molinari Maria Angela³,Contardi Sara⁸,Menozzi Elisa⁹^ORCID,Puzzolante Annette⁶,Vannozzi Giuseppe¹⁰^ORCID,Bergamini Elena¹⁰^ORCID,Pavesi Giacomo⁶,Fraix Valérie¹¹,Meoni Sara¹¹,Fraternali Alessandro¹²,Versari Annibale¹²,Lusuardi Mirco¹³^ORCID,Biagini Giuseppe¹⁴^ORCID,Pinto Serge¹⁵,Moro Elena¹¹^ORCID,Valzania Franco¹^ORCID

Affiliation:

1. Neurology Unit, Neuromotor & Rehabilitation Department Azienda USL‐IRCCS di Reggio Emilia Reggio Emilia Italy

2. Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia Modena Italy

3. Neurology Unit, Department of Neuroscience S. Agostino Estense Hospital, Azienda Ospedaliero‐Universitaria di Modena Modena Italy

4. LAM‐Motion Analysis Laboratory, Neuromotor & Rehabilitation Department Azienda USL‐IRCCS di Reggio Emilia, S. Sebastiano Hospital Correggio Italy

5. Department of Neurosciences, Biomedicine, and Movement Sciences, Institute of Neurosurgery University of Verona Verona Italy

6. Neurosurgery Unit Azienda Ospedaliero‐Universitaria of Modena, Ospedale Civile Baggiovara (OCB) Hospital Modena Italy

7. Division of Neuroradiology, Department of Neuroscience Azienda Ospedaliero‐Universitaria of Modena, OCB Hospital Modena Italy

8. IRCCS Istituto delle Scienze Neurologiche di Bologna, Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore Bologna Italy

9. Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London UK

10. Laboratory of Bioengineering and Neuromechanics of Movement, Department of Movement, Human and Health Sciences University of Rome “Foro Italico” Rome Italy

11. Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes Grenoble Institut Neurosciences, Neurology Department Grenoble France

12. Nuclear Medicine Unit Azienda Unità Sanitaria Locale IRCCS Reggio Emilia Italy

13. Neuromotor & Rehabilitation Department Azienda USL‐IRCCS di Reggio Emilia Reggio Emilia Italy

14. Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Modena Italy

15. Aix‐Marseille University, CRNS, LPL Aix‐en‐Provence France

Abstract

AbstractObjectiveTo evaluate correlations between speech and gait parameters in the long term and under different medication and subthalamic nucleus deep brain stimulation (STN‐DBS) conditions in a cohort of advanced Parkinson's disease (PD) patients.MethodsThis observational study included consecutive PD patients treated with bilateral STN‐DBS. Axial symptoms were evaluated using a standardized clinical‐instrumental approach. Speech and gait were assessed by perceptual and acoustic analyses and by the instrumented Timed Up and Go (iTUG) test, respectively. Disease motor severity was evaluated with the total score and subscores of the Unified Parkinson's Disease Rating Scale (UPDRS) Part III. Different stimulation and drug treatment conditions were assessed: on‐stimulation/off‐medication, off‐stimulation/off‐medication, and on‐stimulation/on‐medication.ResultsTwenty‐five PD patients with a 5‐year median follow‐up after surgery (range 3–7 years) were included (18 males; disease duration at surgery: 10.44 [SD 4.62] years; age at surgery: 58.40 [SD 5.73] years). In the off‐stimulation/off‐medication and on‐stimulation/on‐medication conditions, patients who spoke louder had also the greater acceleration of the trunk during gait; whereas in the on‐stimulation/on‐medication condition only, patients with the poorer voice quality were also the worst to perform the sit to stand and gait phases of the iTUG. Conversely, patients with the higher speech rate performed well in the turning and walking phases of the iTUG.ConclusionsThis study underlines the presence of different correlations between treatment effects of speech and gait parameters in PD patients treated with bilateral STN‐DBS. This may allow us to better understand the common pathophysiological basis of these alterations and to develop a more specific and tailored rehabilitation approach for axial signs after surgery.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.15803

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