Affiliation:
1. Department of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Japan
2. Department of Internal Medicine Kaga Medical Center Kaga Japan
Abstract
AbstractBackgroundLipoprotein (a) [Lp(a)] is associated with coronary artery disease (CAD). However, the role of healthy lifestyle against the risk of CAD with consideration of high Lp(a) levels remains unclear.MethodsThis study examined 4512 participants who underwent serum Lp(a) level assessment at Kanazawa University Hospital from 2008 to March 2016. Their lifestyle habits were examined based on four questionnaires regarding dietary pattern, exercise habits, smoking status and body weight. Logistic regression analyses were performed to identify the association between healthy lifestyle and CAD independent of Lp(a) levels.ResultsThe Lp(a) levels were significantly associated with CAD (odds ratio [OR]: 1.12, 95% confidence interval [CI]: 1.08–1.17, p = 1.3 × 10−7 per 10 mg/dL). Under these circumstances, the lifestyle risk score was also significantly associated with CAD (OR: 1.24, 95% CI: 1.12–1.36, p = 2.4 × 10−8). Compared with patients with a favourable lifestyle who have Lp(a) levels of <30 mg/dL, those with an intermediate or unfavourable lifestyle were at higher risk for CAD (OR: 1.11, 95% CI: 1.02–1.20, p = 0.003 and OR: 1.40, 95% CI: 1.16–1.54, p = 3.6 × 10−5, respectively). Further, patients with a favourable, intermediate or unfavourable lifestyle who have Lp(a) levels of ≥30 mg/dL were at high risk for CAD (OR: 1.21, 95% CI: 1.08–1.34, p = 0.0014; OR: 1.31, 95% CI: 1.14–1.48, p = 1.2 × 10−4; and OR: 1.81, 95% CI: 1.44–2.18, p = 2.2 × 10−7, respectively).ConclusionsHealthy lifestyle was associated with a lower risk of CAD regardless of Lp(a) levels.
Funder
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Japanese Circulation Society
Subject
Clinical Biochemistry,Biochemistry,General Medicine
Cited by
2 articles.
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