Evolution from a first clinical demyelinating event to multiple sclerosis in the REFLEX trial: Regional susceptibility in the conversion to multiple sclerosis at disease onset and its amenability to subcutaneous interferon beta‐1a

Author:

Battaglini Marco1ORCID,Vrenken Hugo2,Tappa Brocci Riccardo1,Gentile Giordano1ORCID,Luchetti Ludovico1,Versteeg Adriaan2,Freedman Mark S.3,Uitdehaag Bernard M. J.4,Kappos Ludwig5,Comi Giancarlo6ORCID,Seitzinger Andrea7ORCID,Jack Dominic8ORCID,Sormani Maria Pia9,Barkhof Frederik210ORCID,De Stefano Nicola1

Affiliation:

1. Department of Medicine, Surgery and Neurosciences University of Siena Siena Italy

2. Department of Radiology and Nuclear Medicine Amsterdam UMC Amsterdam The Netherlands

3. Department of Medicine Ottawa Hospital Research Institute University of Ottawa Ottawa Ontario Canada

4. Department of Neurology Amsterdam UMC, Location VUmc Amsterdam The Netherlands

5. Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) and Neurology Departments of Head, Spine and Neuromedicine Biomedical Engineering and Clinical Research University Hospital University of Basel Basel Switzerland

6. Casa di Cura Privata del Policlinico Università Vita‐Salute San Raffaele Milan Italy

7. Global Biostatistics Merck Healthcare KGaA Darmstadt Germany

8. Global Medical Affairs Merck Serono Ltd (an affiliate of Merck KGaA) Feltham UK

9. Department of Health Sciences University of Genoa Genoa Italy

10. UCL Institutes of Neurology and Healthcare Engineering London UK

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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