Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma

Author:

Casale T. B.1ORCID,Chipps B. E.2,Rosén K.3,Trzaskoma B.3,Haselkorn T.4,Omachi T. A.3,Greenberg S.56,Hanania N. A.7

Affiliation:

1. Division of Allergy and Immunology; University of South Florida; Tampa FL USA

2. Capital Allergy & Respiratory Disease Center; Sacramento CA USA

3. Genentech, Inc.; South San Francisco CA USA

4. EpiMetrix, Inc.; Los Altos CA USA

5. Novartis Pharmaceuticals Corporation; East Hanover NJ USA

6. Department of Medicine; College of Physicians and Surgeons; Columbia University; New York NY USA

7. Section of Pulmonary and Critical Care Medicine; Asthma Clinical Research Center; Baylor College of Medicine; Houston TX USA

Funder

Novartis Pharma

Genentech

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference36 articles.

1. Xolair [package insert] South San Francisco, CA Genentech USA, Inc. 2016

2. European Medicines Agency Xolair summary of product characteristics 2016 http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000606/WC500057298.pdf

3. High eosinophil count: a potential biomarker for assessing successful omalizumab treatment effects;Busse;J Allergy Clin Immunol,2013

4. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials;Castro;Lancet Respir Med,2015

5. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study;Hanania;Am J Respir Crit Care Med,2013

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