Synthesis,In VitroCytotoxicity and Radiosensitizing Activity of Novel 3-[(2,4-Dinitrophenylamino)Alkyl] Derivatives of 5-Fluorouracil

Author:

Khalaj Ali12,Abdi Khosrou13,Ostad Seyed Nasser4,Khoshayand Mohammad Reza5,Lamei Navid2,Nedaie Hasan Ali6

Affiliation:

1. Department of Medicinal Chemistry; Faculty of Pharmacy; Tehran University of Medical Sciences; Tehran Iran

2. Drug Design & Development Research Center; Tehran University of Medical Sciences; Tehran Iran

3. Department of Radiopharmacy; Faculty of Pharmacy; Tehran University of Medical Sciences; Tehran Iran

4. Department of Toxicology and Pharmacology; Faculty of Pharmacy; Tehran University of Medical Sciences; Tehran Iran

5. Department of Drug and Food Control; Faculty of Pharmacy; Tehran University of Medical Sciences; Tehran Iran

6. Department of Radiotherapy; Oncology Cancer Institute; Tehran University of Medical Sciences; Tehran Iran

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference21 articles.

1. Chemical radiosensitizers for use in radiotherapy;Wardman;Clin Oncol,2007

2. Synthesis and hypoxia-selective cytotoxicity of A 2-nitroimidazole mustard;Lee;Bioorg Med Chem Lett,1998

3. Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo;Ahmed;Int J Radiat Oncol Biol Phys,1986

4. Design of hypoxia-targeting drugs as new cancer chemotherapeutics;Nagasawa;Biol Pharm Bull,2006

5. Tao C. Desai N.P. Soon-Shiong P. Sandford P.A. 1996 PCT Int Appl WO 9640091 Chem

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