1-Thia-4,7-diaza-spiro[4.4]nonane-3,6-dione: A Structural Motif for 5-hydroxytryptamine 6 Receptor Antagonism

Author:

Hostetler Greg1,Dunn Derek1,McKenna Beth A.1,Kopec Karla1,Chatterjee Sankar1

Affiliation:

1. Cephalon, Inc.; 145 Brandywine Parkway West Chester PA 19380-4245 USA

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference13 articles.

1. Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology;Marazziti;Curr Med Chem,2013

2. 5-HT6 receptors and Alzheimer's disease;Ramirez;Alzheimers Res Ther,2013

3. Potential role of the 5-HT6 receptor in depression and anxiety: an overview of clinical data;Wesołowska;Pharmacol Rep,2010

4. Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation;Ly;ACS Chem Neurosci,2013

5. 5-HT6 receptor antagonists as potential therapeutics for cognitive impairment;Rossé;Curr Top Med Chem,2010

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