Improving the Thrombin Inhibitory Activity of Glycyrrhizin, a Triterpenic Saponin, Through a Molecular Simplification of the Carbohydrate Moiety-Reference-Cited by-同舟云学术

Improving the Thrombin Inhibitory Activity of Glycyrrhizin, a Triterpenic Saponin, Through a Molecular Simplification of the Carbohydrate Moiety

Published:2013-10-25 Issue:6 Volume:82 Page:756-760
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

de Paula Fernando T.¹,Frauches Petrina Q.¹,Pedebos Conrado²,Berger Markus³,Gnoatto Simone C. B.⁴,Gossmann Grace⁴,Verli Hugo²,Guimarães Jorge A.³,Graebin Cedric S.¹

Affiliation:

1. Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM); Departamento de Química, Instituto de Ciências Exatas; Universidade Federal Rural do Rio de Janeiro; Rodovia BR-465 Km. 7 Seropédica RJ 23897-000 Brazil

2. Grupo de Bioinformática Estrutural; Centro de Biotecnologia; Universidade Federal do Rio Grande do Sul; Av. Bento Gonçalves 9500, Prédios 43431 - Setor IV - Campus do Vale - P.O. Box 15005 Porto Alegre RS 91501-970 Brazil

3. Laboratório de Bioquímica Farmacológica; Centro de Biotecnologia; Universidade Federal do Rio Grande do Sul; Av. Bento Gonçalves 9500, Prédios 43431 - Setor IV - Campus do Vale - P.O. Box 15005 Porto Alegre RS 91501-970 Brazil

4. Laboratório de Fitoquímica; Faculdade de Farmácia; Universidade Federal do Rio Grande do Sul; Av. Ipiranga 2752 Porto Alegre RS 90610-000 Brazil

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12204/fullpdf

Reference16 articles.

1. The anticoagulants market;Melnikova;Nat Rev Drug Discov,2009

2. Stroke prevention in atrial fibrillation: managing the risks in light of new oral anticoagulants;Stroebeck;Cardiovasc Drugs Ther,2012

3. Early postoperative bleeding in polytrauma patients treated with fondaparinux: literature review and institutional experience;Tsiridis;Curr Vasc Pharmacol,2011

4. Identification of glycyrrhizin as a thrombin inhibitor;Francischetti;Biochem Biophys Res Comm,1997

5. Antithrombotic effect of glycyrrhizin, a plant-derived thrombin inhibitor;Mendes-Silva;Thromb Res,2003

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Status and Prospects of Molecular Simulations for Drug Discovery;Journal of the Brazilian Chemical Society;2024

2. Protective effect of soloxolone derivatives in carrageenan- and LPS-driven acute inflammation: Pharmacological profiling and their effects on key inflammation-related processes;Biomedicine & Pharmacotherapy;2023-03

3. In vitro and in vivo anti-inflammatory and anticoagulant activities of Myrciaria plinioides D. Legrand ethanol leaf extract;Inflammopharmacology;2022-02-14

4. Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs;European Journal of Medicinal Chemistry;2022-01

5. Natural products for the prevention and treatment of cholestasis: A review;Phytotherapy Research;2020-02-05