The role of gut microbiota in cerebrovascular disease and related dementia

Author:

Cuartero María Isabel1234ORCID,García‐Culebras Alicia1235ORCID,Nieto‐Vaquero Carmen1234,Fraga Enrique1234,Torres‐López Cristina1234,Pradillo Jesús234,Lizasoain Ignacio234,Moro María Ángeles1234ORCID

Affiliation:

1. Neurovascular Pathophysiology, Cardiovascular Risk Factor and Brain Function Programme Centro Nacional de Investigaciones Cardiovasculares (CNIC) Madrid Spain

2. Departamento de Farmacología y Toxicología, Facultad de Medicina Universidad Complutense de Madrid (UCM) Madrid Spain

3. Instituto de Investigación Hospital 12 de Octubre (i+12) Madrid Spain

4. Instituto Universitario de Investigación en Neuroquímica Universidad Complutense de Madrid (UCM) Madrid Spain

5. Departamento de Biología Celular, Facultad de Medicina Universidad Complutense de Madrid (UCM) Madrid Spain

Abstract

AbstractIn recent years, increasing evidence suggests that commensal microbiota may play an important role not only in health but also in disease including cerebrovascular disease. Gut microbes impact physiology, at least in part, by metabolizing dietary factors and host‐derived substrates and then generating active compounds including toxins. The purpose of this current review is to highlight the complex interplay between microbiota, their metabolites. and essential functions for human health, ranging from regulation of the metabolism and the immune system to modulation of brain development and function. We discuss the role of gut dysbiosis in cerebrovascular disease, specifically in acute and chronic stroke phases, and the possible implication of intestinal microbiota in post‐stroke cognitive impairment and dementia, and we identify potential therapeutic opportunities of targeting microbiota in this context.

Funder

Instituto de Salud Carlos III

Ministerio de Ciencia e Innovación

Publisher

Wiley

Subject

Pharmacology

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