1. Department of Pharmacy; Hokkaido University Hospital; Kita 14-jo; Nishi 5-chome, Kita-ku Sapporo 060-8648 Japan
2. Division of Pharmasciences, Faculty of Pharmaceutical Sciences; Hokkaido University; Kita 12-jo Nishi 6-chome; Kita-ku Sapporo 060-0812 Japan