Prospective evaluation of a telmisartan suppression test as a diagnostic tool for primary hyperaldosteronism in cats

Author:

Kurtz Maxime1ORCID,Fabrès Virginie12,Dumont Renaud3ORCID,Chetboul Valérie4ORCID,Chahory Sabine5,Saponaro Vittorio4,Trehiou Emilie4,Poissonnier Camille4,Passavin Peggy4,Jondeau Coline5,Bott Matthieu5,Buronfosse Thierry6,Benchekroun Ghita17ORCID

Affiliation:

1. Ecole Nationale Vétérinaire d'Alfort – CHUVA, Service de Médecine Interne Maisons‐Alfort France

2. Aquivet Clinique Veterinaire – Service de Médecine Interne Eysines France

3. Centre Hospitalier Veterinaire Fregis Arcueil France

4. École Nationale Vétérinaire d'Alfort – CHUVA, Unité de Cardiologie d'Alfort Maisons‐Alfort France

5. Ecole Nationale Vétérinaire d'Alfort – CHUVA, Unité d'Ophtalmologie Maisons‐Alfort France

6. VetAgro Sup – Service De Biologie Clinique Marcy‐l'Etoile France

7. Ecole Nationale Vétérinaire d'Alfort – University Paris‐Est Créteil, INSERM, IMRB Maisons‐Alfort France

Abstract

AbstractBackgroundIn a previous study, telmisartan suppressed aldosterone secretion in healthy cats but not in cats with primary hyperaldosteronism (PHA).HypothesesTelmisartan suppresses aldosterone secretion in middle‐aged healthy cat and cats with diseases that may result in secondary hyperaldosteronism, but not in those with PHA.AnimalsThirty‐eight cats: 5 with PHA; 16 with chronic kidney disease (CKD), subclassified as hypertensive (CKD‐H) or non‐hypertensive (CKD‐NH); 9 with hyperthyroidism (HTH); 2 with idiopathic systemic arterial hypertension (ISH); and 6 healthy middle‐aged cats.MethodsProspective, cross‐sectional study. Serum aldosterone concentration, potassium concentration, and systolic blood pressure were measured before and 1 and 1.5 hours after PO administration of 2 mg/kg of telmisartan. The aldosterone variation rate (AVR) was calculated for each cat.ResultsNo significant difference in the minimum AVR was observed among groups (median [quartile 1 (Q1); quartile 3 (Q3)]: 25 [0; 30]; 5 [−27; −75]; 10 [−6; −95]; 53 [19; 86]; 29 [5; 78]) for PHA, CKD, HTH, ISH, and healthy cats, respectively (P = .05). Basal serum aldosterone concentration (pmol/L) was significantly higher in PHA cats (median [Q1; Q3]: 2914 [2789; 4600]) than in CKD‐H cats (median [Q1; Q3]: 239 [189; 577], corrected P value = .003) and CKD‐NH cats (median [Q1; Q3]: 353 [136; 1371], corrected P value = .004).Conclusions and Clinical ImportanceThe oral telmisartan suppression test using a single dose of 2 mg/kg telmisartan did not discriminate cats with PHA from healthy middle‐aged cats or cats with diseases that may result in secondary hyperaldosteronism.

Publisher

Wiley

Subject

General Veterinary

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