γT -S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo
Author:
Affiliation:
1. Canadian Blood Services, Centre for Innovation; Hamilton ON Canada
2. Department of Pathology and Molecular Medicine; McMaster University; Hamilton ON Canada
3. Department of Medicine; McMaster University; Hamilton ON Canada
Funder
Canadian Blood Services
Canadian Institutes of Health Research
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.12601/fullpdf
Reference18 articles.
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2. A specific antidote for dabigatran: functional and structural characterization;Schiele;Blood,2013
3. Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model;Grottke;Crit Care,2014
4. Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate;Lambourne;J Thromb Haemost,2012
5. Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran;Zhou;Stroke,2011
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