A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel <scp>KCNQ4</scp> mutation (p. <scp>G228D</scp> ) from a large Chinese family-Reference-Cited by-同舟云学术

A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel KCNQ4 mutation (p. G228D ) from a large Chinese family

Published:2022-05-28 Issue:2 Volume:102 Page:149-154
ISSN:0009-9163
Container-title:Clinical Genetics
language:en
Short-container-title:Clinical Genetics

Author:

Cui Chong¹²,Zhang Luping³^ORCID,Qian Fuping⁴,Chen Yuxin¹²,Huang Bowei¹²,Wang Fang¹²,Wang Daqi¹²,Lv Jun¹²,Wang Xuechun³,Yan Zhiqiang⁵,Guo Luo¹,Li Geng‐Lin¹,Shu Yilai¹²,Liu Dong⁴⁶,Li Huawei¹²

Affiliation:

1. ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, NHC Key Laboratory of Hearing Medicine Fudan University Shanghai China

2. Institutes of Biomedical Sciences Fudan University Shanghai China

3. Department of Otolaryngology‐Head and Neck Surgery Affiliated Hospital, Nantong University Nantong China

4. School of Life Sciences, Nantong Laboratory of Development and Diseases Nantong University Nantong China

5. Institute of Molecular Physiology Shenzhen Bay Laboratory Shenzhen China

6. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co‐innovation Center of Neuroregeneration, Nantong University Nantong China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cge.14164

Reference17 articles.

1. Newborn Hearing Screening — A Silent Revolution

2. Targeted High-Throughput Sequencing Identifies Pathogenic Mutations in KCNQ4 in Two Large Chinese Families with Autosomal Dominant Hearing Loss

3. KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss

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