A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers
Author:
Affiliation:
1. d3 Medicine; A Certara Company; Parsippany New Jersey USA
2. Linear Clinical Research; Perth Australia
3. Principia Biopharma; Melbourne Australia
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.13351/fullpdf
Reference17 articles.
1. The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy;Crofford;Expert Rev Clin Immunol,2016
2. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis;Di Paolo;Nat Chem Biol,2011
3. Bruton's tyrosine kinase-an integral protein of B cell development that also has an essential role in the innate immune system;Lopez-Herrera;J Leukoc Biol,2014
4. The many faces of Bruton's tyrosine kinase;McAtee;Nat Biotechnol,2012
5. Bruton's tyrosine kinase as a drug discovery target;Pan;Drug News Perspect,2008
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