Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson's disease and does not lead to a sustainable increase of brain‐derived neurotrophic factor-Reference-Cited by-同舟云学术

Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson's disease and does not lead to a sustainable increase of brain‐derived neurotrophic factor

Published:2018-11-13 Issue:5 Volume:147 Page:678-691
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J. Neurochem.

Author:

Komnig Daniel¹^ORCID,Dagli Toruntay Cem¹,Habib Pardes¹,Zeyen Thomas¹,Schulz Jörg B.¹²^ORCID,Falkenburger Björn H.¹²^ORCID

Affiliation:

1. Department of Neurology RWTH Aachen University Aachen Germany

2. JARA‐BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University Aachen Germany

Funder

Novartis

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.14575

Reference53 articles.

1. Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration

2. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

3. Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

4. Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain

5. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

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