Adjuvant Effect of CpG-Oligodeoxynucleotide in Anti-Fungal Chemotherapy against Fatal Infection withCryptococcus neoformansin Mice

Author:

Kinjo Takeshi1,Miyagi Kazuya1,Nakamura Kiwamu12,Higa Futoshi1,Gang Xiao3,Miyazato Akiko24,Kaku Mitsuo24,Fujita Jiro1,Kawakami Kazuyoshi34

Affiliation:

1. Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine; University of the Ryukyus; Okinawa 903-0215 Japan

2. Department of Infection Control and Laboratory Diagnostics, Internal Medicine; Tohoku University Graduate School of Medicine; Sendai Miyagi 980-8575 Japan

3. Microbiology and Immunology, Department of Medical Technology, School of Health Sciences, Faculty of Medicine; Tohoku University; Sendai Miyagi 980-8575 Japan

4. Infection-Control Research Center; Tohoku University Hospital; Sendai Miyagi 980-8575 Japan

Publisher

Wiley

Subject

Virology,Immunology,Microbiology

Reference21 articles.

1. The effects of amphotericin B, fluconazole and miconazole on neutrophil and lymphocyte function in a guinea pig model;Drummond;J. Antimicrob. Chemother.,1995

2. Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner;Edwards;Eur. J. Immunol.,2005

3. A toll-like receptor recognizes bacterial DNA;Henmi;Nature,2000

4. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA;Jakob;J. Immunol.,1998

5. In vivo activity of interferon-gamma in combination with amphotericin B in the treatment of experimental cryptococcosis;Joly;J. Infect. Dis.,1994

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