Long‐term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A

Author:

Nolan B.1,Mahlangu J.2,Perry D.3,Young G.4,Liesner R.5,Konkle B.6,Rangarajan S.7,Brown S.8,Hanabusa H.9,Pasi K. J.10,Pabinger I.11,Jackson S.12,Cristiano L. M.13,Li X.13,Pierce G. F.13,Allen G.13

Affiliation:

1. Our Lady's Children's Hospital Dublin Ireland

2. University of the Witwatersrand Faculty of Health Sciences Johannesburg South Africa

3. Addenbrookes Hospital Cambridge UK

4. Children's Hospital Los Angeles University of Southern California Keck School of Medicine Los Angeles CA USA

5. Great Ormond Street Hospital London UK

6. Puget Sound Blood Center Seattle WA USA

7. Basingstoke and North Hampshire Hospital Basingstoke UK

8. Lady Cilento Children's Hospital Brisbane Qld Australia

9. Ogikubo Hospital Tokyo Japan

10. Barts and the London Comprehensive Care Center London UK

11. Medizinsche Universitat Wien Vienna Austria

12. St Paul's Hospital Vancouver BC Canada

13. Biogen Cambridge MA USA

Funder

Biogen

Bayer

CSL Behring

Novo Nordisk

Baxter International

Pfizer

Publisher

Wiley

Subject

Genetics(clinical),Hematology,General Medicine

Reference15 articles.

1. The Hemophilias — From Royal Genes to Gene Therapy

2. National Hemophilia Foundation.Medical and Scientific Advisory Council (MASAC) recommendation concerning prophylaxis (regular administration of clotting factor concentrate to prevent bleeding) 2007. Available athttp://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=57&contentid=1007. Accessed May 28 2015

3. Prophylaxis versus Episodic Treatment to Prevent Joint Disease in Boys with Severe Hemophilia

4. Population pharmacokinetics of recombinant factor VIII: the relationships of pharmacokinetics to age and body weight

5. Barriers to compliance with prophylaxis therapy in haemophilia

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