Efficacy and safety of a novel mucoadhesive clobetasol patch for treatment of erosive oral lichen planus: A phase 2 randomized clinical trial

Author:

Brennan Michael T.1ORCID,Madsen Lars Siim2,Saunders Deborah P.34,Napenas Joel J.1,McCreary Christine5,Ni Riordain Richeal5,Pedersen Anne Marie Lynge6ORCID,Fedele Stefano7ORCID,Cook Richard J.8,Abdelsayed Rafik9,Llopiz Maria T.10,Sankar Vidya1112,Ryan Kevin13,Culton Donna A.14,Akhlef Yousra15,Castillo Fausto16,Fernandez Inti17,Jurge Sabine18,Kerr Alexander R.19,McDuffie Chad20,McGaw Tim21,Mighell Alan22,Sollecito Thomas P.23,Schlieve Thomas24ORCID,Carrozzo Marco25,Papas Athena12,Bengtsson Thomas26,Al‐Hashimi Ibtisam2427,Burke Laurie28,Burkhart Nancy W.29,Culshaw Shauna13,Desai Bhavik9,Hansen Jens2,Jensen Pia2,Menné Torkil30,Patel Paras B.31,Thornhill Martin18,Treister Nathaniel11,Ruzicka Thomas32

Affiliation:

1. Department of Oral Medicine Atrium Health Carolinas Medical Center Charlotte North Carolina USA

2. Afyx Therapeutics A/S Copenhagen Denmark

3. Health Sciences North Northeast Cancer Centre Sudbury Ontario Canada

4. Northern Ontario School of Medicine Sudbury Ontario Canada

5. College of Medicine and Health Cork University Dental School and Hospital University College Cork Cork Ireland

6. University of Copenhagen Department of Odontology Copenhagen Denmark

7. UCL Eastman Dental Institute and UCLH NIHR Biomedical Research Centre University College London London UK

8. Faculty of Dentistry Oral & Craniofacial Sciences Oral Medicine & Oral Clinical Research Unit Guy’s Hospital Campus King's College London London UK

9. The Dental College of Georgia Augusta University Augusta Georgia USA

10. Vitae Research Center LLC Miami Miami Florida USA

11. Division of Oral Medicine and Dentistry Brigham and Women's Hospital Boston Massachusetts USA

12. Tufts University School of Dental Medicine Boston Massachusetts USA

13. University of Glasgow Hospital & Dental School Glasgow UK

14. Department of Dermatology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

15. Department of Oral & Maxillofacial Surgery Copenhagen University Hospital (Rigshospitalet) Copenhagen Denmark

16. QWay Research Hialeah Florida USA

17. Valencia Medical & Research Center Miami Florida USA

18. University of Sheffield School of Clinical Dentistry Sheffield UK

19. NYU College of Dentistry New York New York USA

20. ENT Associates of Texas Frisco Texas USA

21. Kaye Edmonton Clinic Edmonton Alberta Canada

22. School of Dentistry The University of Leeds Leeds UK

23. School of Dental Medicine University of Pennsylvania Philadelphia Pennsylvania USA

24. UT Southwestern Medical Center Dallas Texas USA

25. School of Dental Sciences Newcastle University Newcastle UK

26. Statmind AB Lund Sweden

27. Scientific Consultant Dallas Texas USA

28. LORA Group Royal Oak Maryland USA

29. The International Oral Lichen Planus Support Group Texas A&M University College of Dentistry Dallas Texas USA

30. Scientific Consultant Copenhagen Denmark

31. Texas A&M University College of Dentistry Dallas USA

32. Ludwig‐Maximilian University Munich Germany

Funder

Innovationsfonden

Publisher

Wiley

Subject

Periodontics,Cancer Research,Otorhinolaryngology,Oral Surgery,Pathology and Forensic Medicine

Reference19 articles.

1. Lichen Planus

2. Global Prevalence and Incidence Estimates of Oral Lichen Planus

3. Topical application of drugs used in treatment of oral lichen planus lesions;Radwan‐Oczko M;Adv Clin Exp Med,2013

4. Oral lichen planus: An update on etiology, pathogenesis, clinical presentation, diagnosis and management

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