Different routes and formulations of melatonin in critically ill patients. A pharmacokinetic randomized study

Author:

Mistraletti Giovanni12ORCID,Paroni Rita3,Umbrello Michele2,Moro Salihovic Bedrana1,Coppola Silvia2,Froio Sara2,Finati Elena3,Gasco Paolo4,Savoca Adriana5,Manca Davide5,Chiumello Davide23,Reiter Russel J.6,Iapichino Gaetano12

Affiliation:

1. Department of Pathophysiology and Transplantation Università degli Studi di Milano Milano Italy

2. S.C. Anesthesia and Intensive Care ASST Santi Paolo e Carlo, Ospedale San Paolo‐Polo Universitario Milano Italy

3. Department of Health Science Università degli Studi di Milano Milano Italy

4. Nanovector srl Torino Italy

5. Chemical Engineering Department Politecnico di Milano Milano Italy

6. Department of Cellular and Structural Biology University of Texas Health Science Centre San Antonio Texas

Funder

Regione Lombardia

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism,Endocrinology

Reference35 articles.

1. Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial;Mistraletti G;Minerva Anestesiol,2015

2. Melatonin pharmacological blood levels increase total antioxidant capacity in critically ill patients;Mistraletti G;Int J Mol Sci,2017

3. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies;Wilhelmsen M;J Pineal Res,2011

4. Effects of melatonin treatment in septic newborns;Gitto E;Pediatr Res,2001

5. Potential use of melatonin in sleep and delirium in the critically ill;Bellapart J;Br J Anaesth,2012

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