Serum uric acid and Parkinson's disease: A systematic review and meta‐analysis-Reference-Cited by-同舟云学术

Serum uric acid and Parkinson's disease: A systematic review and meta‐analysis

Published:2023-06-09 Issue:6 Volume:11 Page:299-309
ISSN:2049-4173
Container-title:Neurology and Clinical Neuroscience
language:en
Short-container-title:Neurology & Clinical Neurosc

Author:

Balabandian Mohammad¹²,Salahi Sarvenaz³,Mahmoudvand Behnaz²,Esmaeilzadeh Mahla⁴,Hashemi Seyedeh Melika⁵,Nabizadeh Fardin¹²^ORCID

Affiliation:

1. Neuroscience Research Group (NRG) Universal Scientific Education and Research Network (USERN) Tehran Iran

2. School of Medicine Iran University of Medical Sciences Tehran Iran

3. Minimally Invasive Surgery Research Center Tehran Iran

4. Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran

5. School of Medicine Tehran University of Medical Sciences Tehran Iran

Abstract

AbstractBackgroundNumerous studies attempted to fully understand the association between serum uric acid (UA) and Parkinson's disease. Due to the contradictory results, we aimed to perform a systematic review and meta‐analysis to investigate the association between UA and PD.MethodsWe conducted a literature search in the electronic databases: PubMed, Web of Science, and Scopus. We included all studies comparing serum uric acid in PD patients and control subjects.ResultsAfter the screening, 30 studies met our inclusion criteria and entered our systematic review and meta‐analysis. The mean difference (MD) of UA between PD and control using a random‐effect model was −00.49 (95% CI −0.65, −0.33).ConclusionOur results suggests that serum levels of UA are significantly lower in patients with PD than in healthy subjects. However, further studies are needed to clarify the association of geographic region, PD progression, and PD treatment with UA serum levels.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ncn3.12761

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